Since the first birth of IVF in 1978, it has been 40 years. From the beginning, eighty sperm has to be implanted into the egg for fertilization. Nowadays, as technology develops, the fertilization implants one sperm only (ICSI). With the genetic technology application, we can screen the chromosomes to identify whether the embryo is normal, in the meanwhile, we can distinguish the gender of embryos as well.
The clinical definition of infertility provided by the World Health Organization is “a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse.”
According to a systematic analysis of national health surveys, in 2010, approximately 10.5% of women around the world experienced secondary infertility, and roughly 2% experienced primary infertility. The prevalence of secondary infertility, in particular, varies widely by region and country, ranging from less than 6% to greater than 16% of women.
A record one in twenty babies was born through in vitro fertilization treatment in Japan in 2015, a recent tally showed.
The upward trend in the number of IVF treatments is expected to continue as more couples are marrying later in life and increasingly turning to infertility treatment, according to experts.
The survey by the Japan Society of Obstetrics and Gynecology (JSOG) found a record of 424,151 in vitro fertilizations were performed in 2015, resulting in 51,001 births, also an all-time high.
Since the first IVF birth in Japan in 1983 through to 2015, there have been a total of about 482,600 children born via the procedure in the country.
In the United States, third-party reproductive (surrogacy, egg/sperm donation) as conventional treatment, stands for a hope for women who cannot conceive themselves, lost families, LGBT, single parents to have their babies. Miracle Angels helps the intended parents to realize their dream of having a baby via the highest reproductive technology in the world.
The following process is for reference only. Please refer to the treatment plan given by the IVF physician.
Initial consulting with Miracle Angels, let us know your requirements.
The intended mother undergoes AMH, hormones, and follicle tests at day third of the menstrual period. The intended father undergoes semen analysis. If intended parents plan to conceive babies via surrogacy, we highly recommend intended parents to undergo STD tests.
Once the results come out, Miracle Angels will initiate a consultation with an IVF physician for intended parents. The international intended parents could attend the consultation remotely.
Preparation prior to IVF cycle
The intended mother could take prenatal supplements or CoQ10 for at least three weeks, and some of the time take birth control pills on day seventeenth of the menstrual period.
Once the intended mother gets a menstrual period, Miracle Angels will schedule the appointment for intended parents with an IVF clinic.
The initial appointment is a day between day second till day fifth of the menstrual period, the intended mother goes back to the IVF clinic on day eighth, tenth and twelfth of the menstrual period. Based on the intended mother’s hormone level, IVF physician will prescribe a trigger on day twelfth and retrieve the eggs on the day fourteenth. International intended parents could undergo monitoring locally and come to Japan for egg retrieval only.
Insemination and embryo culture
The laboratory will screen the maturity of the eggs and perform single sperm injection (ICSI) on the same day of egg retrieval. Then culture the fertilized eggs in the laboratory for five or six days.
PGS stands for pre-transfer genetic screening, which will screen chromosomes of the embryos. Therefore, the embryologists could distinguish the genders of the embryos. Also, normal embryos will reduce the risks of miscarriage and abnormalities of the fetus. PGD stands for pre-transfer diagnosis, which will diagnose specific genetic issues. It is a good option for the intended parents who carry the same family genetic history.
Frozen Embryo Transfer
The intended parents could undergo embryo transfer anytime when they would like to build or expand their family with frozen embryos. Compared with fresh embryo transfer. Frozen embryo transfer performs a better success rate. Because it is much easier for IVF doctors to regulate the intended mother’s lining and find a better window of transfer time，the intended mother will take injectable medication and undergo an embryo transfer procedure on the day twentieth of the menstrual period approximately.
Monitor after FET
After embryo transfer, the clinic will continue monitoring the intended mother until the tenth week of pregnancy.